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Symbol
Name
ID 		Thpo
thrombopoietin
MGI:101875
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA level
Increased circulating IgE level
Abnormal bleeding
Epistaxis
Joint hemorrhage
Persistent bleeding after trauma
Prolonged bleeding time
Bruising susceptibility
Petechiae
Abnormal bone marrow cell morphology
Abnormal megakaryocyte morphology
Increased megakaryocyte colony forming unit count
Increased megakaryocyte count
Increased micromegakaryocyte count
Increased multinucleated megakaryocyte count
Megakaryocyte nucleus hyperlobulation
Bone marrow hypocellularity
Myelofibrosis
Aplastic anemia
Anemia of inadequate production
Poikilocytosis
Acanthocytosis
Leukocytosis
Acute leukemia
Acute myeloid leukemia
Chronic myelogenous leukemia
Arterial thrombosis
Venous thrombosis
Hepatic vein thrombosis
Abnormality of thrombocytes
Impaired ADP-induced platelet aggregation
Impaired collagen-induced platelet aggregation
Impaired epinephrine-induced platelet aggregation
Abnormal platelet morphology
Thrombocytopenia
Congenital thrombocytopenia
Intermittent thrombocytopenia
Thrombocytosis
Abnormal platelet shape
Abnormal platelet volume
Decreased mean platelet volume
Myelodysplasia
Splenomegaly
Disease(s) Associated with THPO
aplastic anemia
essential thrombocythemia
thrombocytopenia

Mouse Phenotypes
decreased megakaryocyte cell number
thrombocytopenia
increased mean platelet volume
Availability Mouse Genotype
Thpotm1.1(KOMP)Vlcg/Thpotm1.1(KOMP)Vlcg
Thpotm1Mwm/Thpotm1Mwm
Thpotm1Mwm/Thpo+
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory